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As an example, a BCS Class II compound, permeable but relatively insoluble, would likely not be a good clinical candidate without the use of enhanced. Dec 22, 2017 - FDA has issued a final guidance entitled Waiver of In-vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Oral. Bcs ii drugs. For other uses of the abbreviation BCS, see BCS (disambiguation). The Biopharmaceutics Classification System is a system to differentiate the drugs on the basis. Class II - high permeability, low solubility. Example: glibenclamide.